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Research
Projects:
1.
Autoclaved Leishmania major vaccine in
prevention of kala-azar in Sudan. A TDR sponsored Project. (Sponsor:
TDR/WHO project ID 950628).
2. ALUM/Autoclaved
Leishmania major
vaccine in healthy Sudanese volunteers in Khartoum. (Sponsor:
TDR/WHO project ID 980971)
3. Immunochemotherapy of Post kala-azar dermal
leishmaniasis: safety, immunogenecity & possible efficacy. (Sponsor:
TDR/WHO project ID A30468).
4. Alum/Autoclaved
Leishmania major
in children: an extended Phase II in the eastern Sudan. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
5. Tuberculous lymphadenitis: a molecular
biological study of aetiological factors. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
Research
in Progress:
1.
Vaccine-linked treatment of persistent Post-Kala-azar
Dermal Leishmaniasis. (Sponsor:
TDR/WHO).
2.
Induction & maintenance of memory following
Alum/ALM + BCG vaccination in healthy volunteers. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
3.
Developing a protocol for the management of
patients with SSG-unresponsive visceral leishmaniasis. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
4. Anti-leishmania
antibodies and their role in disease dissemination and
disease elimination following SSG treatment. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
5. The
mechanisms of drug unresponsiveness in patients with
visceral leishmaniasis: a possible role for antigenic
heterogeneity. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
6. Anaemia
of Visceral leishmaniasis: Possible role for a blunt
erythropoietin response. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
7.
Renal affection in visceral leishmaniasis:
finding sensitive markers.
8. Tuberculous
lymphadenitis, clinical, cytological, and microbiological
and drug response aspects: towards developing a clinical
algorithm to improve patients’ management. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
9. The
origin of βs gene haplotypes in the Myssieria
tribe of Western Sudan: a moleculo-biological study, towards
developing a community-based card/registry scheme for the
control of sickle cell disease. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
10. The
febrile child: towards developing a clinical algorithm to
improve patients’ management. Collaborative study with the
Central Police Hospital (Waiting for funding).
11. Molecular
epidemiology of multi-drug resistant
P.falciparum
in Sudan: a GIS approach. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
12.
Cytogenetic aberrations in cord blood: a look
into the future
(Waiting for
funding).
13. Diabetes
mellitus: Prevalence of specific mutant genes
(D76N, C18R and R197H) in Sudanese patients
with type II diabetes. Cellular and humoral immune response
profiles in Sudanese patients with type II diabetes: matoux
test in vitro responses to PPD and MSP-119. Sero-prevalence
of GAD and IA2 auto-antibodies among Sudanese patients with
Diabetes mellitus type I.
(Private funding).
14. Haematology:
prevalence of inhibitors. Characterization of molecular
defects in haemophilic Sudanese patients. BCR-ABL protein, a
diagnostic marker in patients with CML: a proteomic
approach.
(Private funding).
15. Phenotypes
and genotypes of major Sudanese tribes: a study of
ethnology. (Sponsor:
Institute of Endemic Diseases, University of
Khartoum).
16. Pregnancy-associated
malaria: Prevalence, maternal & neonatal immune responses.
Determining residual malaria-specific memory following
neonatal malaria. Experimental pregnancy-associated and
neonatal malaria, changing malaria vaccination policy.
(Private funding).
17. The
role of amodiaquine/Artesunate Vs Chlorquine home management
in reducing malaria burden in a cluster of villages along
the White Nile.
(Sponsor:
White Nile State).
18. PfEMP-1
antigenic variation: a moleculo-proteomic study. (Waiting
for funding).
19. The
role of Multiplicity of
P.falciparum
infection in the development of protective immunity against
malaria. (Waiting
for funding)
20. Malaria
burden in an area of stable transmission in eastern Sudan:
possible role for Hb S, Hb F levels and G-6-P-D deficiency.
(Sponsor:
Institute of Endemic Diseases, University of
Khartoum). |
