Institute of Endemic Diseases - SUDAN

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Malaria

 

 
 
 

Publications and Abstracts:

  1. ELhassan I. M (1986) Schistosoma mansoni: Infectivity of cercariae by cutaneous and oral routes.  M.Sc. Dissertation August 1988 (Liverpool of Tropical Medicine, UK).

  2. Saeed BO, Hassabalrasoul MA, Ibrahim KE, Salih SA, Elhassan I.M, Kider S, and Bayoumi RA. (1990). Plasma chloroquine measurement in the evaluation of Plasmodium falciparum sensitivity.  J.Trop.Med.Hyg.  93: 393-396.

  3. Ibrahim ME, Elhassan IM, Elmoubark EA and Awad-Karim FM(1991) A case of P. falciparum malaria sensitive to chloroquine but resistant to  pyrimethamine/ sulfadoxine in Sennar, Sudan, Trans. R. Soc. Trop. Med. Hyg. 85: 446-447

  4. Elhassan IM, Satti G.M.H, Abed-Elkariem A., Fadul I., Elkhalifa A.A, Abedelrahim A.M, Ming C. and Theander T.G. (1993), The efficacy of artemether in the treatment of P.  falciparum malaria in the Sudan. Trans. R. Soc. Trop. Med. Hyg. 87: 685-686.

  5. Hviid L., Theander TG, Elhassan I. M, Jansen J.B (1993) Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-Selectin) during acute  P. falciparum malaria, Immunology letters, 36(1993) 51-58

  6. Hviid L., Elhassan I. M, Dodoo D., Jansen J.B, Bygbjerg I.C, Satti G.M.H, Theander T.G. (1994), Differential T-cell expression of LFA-1 in residents from Africa and Denmark. Description of the phenomenon and its possible basis. Immunol Lett 39: 147-151.

  7. Elhassan I. M, Hviid L., Satti G.M.H, B. Åkerstrom, Jakobsen P.H, Jansen J.B and Theander T. (1994), Plasma markers in P. falciparum: Evidence of endothelial inflammation, T cell activation, T-cell reallocation during uncomplicated disease episodes. Am. J. Trop. Med. Hyg. 51: 372-379.

  8. Jakobsen P.H, Jansen, Morris-Jones, Rønn. A, Hviid L., Theander T.G, Elhassan I.M, Bygbjerg I.C, and Greenwood BM., (1994), Increased plasma concentrations of sICAM, sVCAM-1, and sELAM-1 in patients with P. falciparum or P. vivax malaria and association with disease severity.Immunology.83 665-669.

  9. Elhassan I. M, Hviid L., Arnot E.D, Roper C. and Theander G.T. (1995), Is immunity against P. falciparum malaria acquired by individuals living in seasonal and unstable malaria transmission area? Sud. Med. J.:33(1) 101-104.

  10. Elhassan I. M, Hviid L., Jakobsen P.H, Giha H, Satti G.M.H, Arnot E.D, Jansen J.B and Theander G.T. (1995). Antibodies to Plasmodium falciparum antigens as markers of seasonal variation in exposure to malaria parasites. Abstract Ann Trop. Med. Parasitology 89: 189,

  11. Roper C., Elhassan I.M, G Satti, AA sultan, S Keys, HA Babiker, D.E. (1995), Malaria transmission and the Ro value question. A PCR based approach. Sudan. Med. J.:33(1) 31-39.

  12. Elhassan I. M (1995) Immunol-epiemiological studies of P. falciparum malaria in easter sudan, Ph. D thesis University of Copenhagen, Denmark.

  13. Elhassan I. M, Hviid L., Jakobsen P.H, Geha H., Satti G, Arnot E.D, Jansen J.B, and Theander G.T. (1996), High proportion of sub clinical P. falciparum malaria infection in an area of seasonal and unstable malaria transmission in Sudan Am. J. Trop. Med. Hyg.   53;78-83.

  14. Hviid L, Elhassan IM, Jakobsen PH, Abu-Zeid YA, Jensen JB, Theander TG. The cause of in vitro non-responsiveness of peripheral T cells from acut P. falciparum malaria patients. Studies from Eastern Sudan.  Sud.Med.J. 1995;33:145-149.

  15. Roper C., Elhassan I. M, Hviid L, Giha H., Satti G., Richardson W., Theander T.G and Arnot D.E., (1996), Detection of a very low P. falciparum parasitaemia by nested Polymerase chain reaction and the reassessment of the epidemiology of unstable malaria in Sudan. Am. J. Trop. Med. Hyg.   54;325-331.

  16. Roper C., Richardson W,  Elhassan I. M, H. Giha, Hviid L, Satti G., Theander T.G and Arnot D.E. (1998) Seasonal change in P. falcipaum population in individuals and their relationship to clinical malaria: a longitudinal study in a Sudanese village.  Parasitology 116, 501-510).

  17. Staalsø T, Khalil E. A, Elhassan I. M, Zijlstra E. E, Elhassan A. M, Giha H, Theander T. G, and Jakobsen P .H, (1998), Antibody reactivity to conserved linear epitopes of P.  falciparum erythrocyte membrane protein 1. Immunology letter  60: 121-126.

  18. Giha, H. A., Theander, T. G., Staalsø, T., Roper, C., Elhassan, I. M., Babiker, H., Satti, G. M.  H., Arnot, D. E. & Hviid. L. (1998). Seasonal variation in agglutination of P  falciparum -infected erythrocytes. American Journal of Tropical Medicine Hygiene 58, 399-405.

  19. Cavanagh D.R, Elhassan I. M, Roper C, Robinson VJ, Giha H, Holder A.A, Hviid L, Theander T.G, Arnot D.E, and McBride J. S (1999) A longitudinal study of type specific antibody response to P. falciparum: merozoite surface protein-1 in an area of unstable malaria in Sudan, J. Immunology 161: 347-359.

  20. Giha H A,  Staalsoe T, Dodoo D , Elhassan I. M,  C. Roper, Satti G, Arnot D. E, Hviid L and  Theander T.G (1999)  Overlapping antigenic repertoires of variant antigens expressed on the surface of infected erythrocytes by P.  falciparum,  Parasitol, 119. 7-17.

  21. Giha H.A, Staalsoe T, Dodoo D, Elhassan I.M, Roper C, Satti G.M.H, , Arnot D.E, Theander T.G, Hviid L. (1999). Nine year Longitudinal study of antibodies to variant antigens on the surface of P. falciparum-infected erythrocytes Infection and Immunity 67: 4092-4098.

  22. Funjungo P. N., Elhassan I.M, Cavanagh D.R, Theander T.G, Hviid L, Roper C,   Arnot D.E, and McBride J.S (1999)  A Longitudinal study  of human antibody responses to P.  falciparum Rhoptry-associated protein 1 in a region of seasonal and unstable malaria transmission. Infections and immunity 67:2975-2985.

  23. Hamad AA, El Hassan IM, Ahmed GI, El Khalifa AA, Abdelrahim SA, Theander TG and Arnot D. Chronic P .falciparum infections in an area of low intensity malaria transmission in the Sudan. Parasitology 120: 447-456, 2000

  24. Cavanagh D.R, Dobano-Lazaro, Marsh K, Elhassan I. M, A. M Elhassan, Khalil E. A, , Theander T.G, Arnot D.E, and McBride J.S (2001) Differential patterns of Human IgG subclass responses to distinct regions of merozoite surface protein 1 (MSP-1) of P. falciparum, infection and immunity (2001).

  25. 25.  Staalose T., Hamad AA, Hviid L., El Hassan IM, Arnot D, and Theander TG. (2002). In vivo switching between variant surface antigens in human P. falciparum malaria Journal of infectious diseases 186:719-722.

  26. AM Musa ; EAG Khalil ; MA A/Raheem ; EE Zijlstra ; ME Ibrahim ; IM Elhassan ; MM Mukhtar  & AM EL Hassan. (2002), Natural History of Sudanese Post Kala-azar Dermal Leishmaniasis: Clinical, Immunological & prognostic  features., Annuals of Trop. Med & Pparasitology vol. 96, 765-772.

  27. EE Zijlstra, A Musa, EAG Khalil, IM El Hassan, and AM El-Hassan, (2003) Post-kal-Azar Dermal Leishmaniasis(PKDL) The Lancet infectious Diseases V: 3  87- 98.

  28. Musa AM; Khalil EAG; Ismail A; Elhassan IM; Fesharki H; Khamesipour A; Modabber F, Zijlstra EE; & El-Hassan AM (2004). Safety, immunogenicity  and possible efficacy of Immunochemotherapy of persistent post kala-azar dermal leishmaniasis (PKDL) Annuals of Trop. Med & Pparasitology (submitted).

  29. EAG Khalil; Nahla B. Ayed; AM Musa; Ibrahim ME; Mukhtar MM; Zijlstra EE; Elhassan IM; P.G.Smith; PM. Kieny; Ghalib HW; F.Zicker; Modabber F; Elhassan AM (2006)  Dichotomy of protective cellular immune responses to human visceral leishmaniasis. J of clinical and Experiential Medicine (in press).

  30. Ismail, E.A.G. Khalil, A.M. Musa, I.M. EL Hassan, M.E. Ibrahim, T.G. Theander and A.M. EL Hassan (2006) The pathogenesis of post kala-azar dermal leishmaniasis from the field to the molecule: Does ultraviolet light (UVB) radiation play a role? Medical Hypotheses, In Press.

  31. Ismail, E.A.G. Khalil, A.M. Musa, I.M. EL Hassan, M.E. Ibrahim, T.G. Theander and A.M. EL Hassan (2007) The immunopathogenesis of post kala-azar dermal leishmaniasis (PKDL) (submitted).