Institute of Endemic Diseases - SUDAN

 

 
 

 

CURRICULUM VITAE PRIVATE

 

1.     Personal History:

Full Name: IBRAHIM MOHAMED ELHASSAN Nationality: Danish

Date Of Birth: 12.06.59 Material status: married, 3 children

 

2. Educational qualifications:

2.1 Basic qualification:

1992-1996: Ph. D.  Faculty of Health Sciences, Copenhagen University, Denmark 

1995: Diploma of Tropical Medicine & Hygiene, Copenhagen University.

1985 -1987: M.Sc. Parasitology and Medical Entomology, Liverpool School of Tropical Medicine, University of Liverpool, U.K.

1985- 86: M.Sc. Preliminary year, Equivalent of the British Honours Degree, University of Liverpool, UK.

1979 -1983: B.Sc. in Science (Zoology), University of Zagazig, Egypt.

1975 -78: Sudanese High Secondary School Certificate, Khartoum, Sudan.

1972 -75: Sudanese General School Certificate.

2.3 Short term Training:

Attended a number of international workshops and training courses, including the following:

  • Good Clinical Practice Course WHO/TDR/DNDi Khartoum 26th-27th September, 2004.

  • African malaria Research leader’s management training workshop, Arusha Tanzania, October 6-12 2002.

  • Workshop on Health research Ethics and good Clinical practice, 22-26 July 2002, University of Pretoria, South Africa.

  • Visiting scientist to the Department of Immunology, University of Edinburgh, Scotland, and (10th June-10th July 1998).

  • Visiting scientist to the Department of Genetics, Institute of Cell, Animal and Population Biology, University of Edinburgh, Scotland (17th –27th August1994).

  • Basic Statistics for Medical Researchers, Statistical Research Unit, University of Copenhagen, (8th February –22nd March 1994).

  • Immunological Techniques and Hybridoma Techniques Institute of Medical Microbiology an Immunology, University of Copenhagen (14th –25th March 1994).

  • Practical Course in Cellular Immunology, Department of Medical Anatomy, University of Copenhagen, Denmark (18th –24th November 1993).

  • Immunology and Pathogenesis of Parasitic Diseases, Faculty of Medicine, Copenhagen University, Denmark (15th -19th  March 1993)

  • Electrophoresis Course, Panum Institute, University of Copenhagen, Denmark (20-27th June 1992).

  • Advanced Study Course in Epidemiology and Biostatistics, The Nordic School of Public Health, Gothenburg, Sweden (11th -22nd  May1992)  

  • Parasitic Diseases: Advanced laboratory Diagnosis Course, London School of Tropical Medicine, University of London, U.K, 3rd –14th September 1990.

  • Introduction to Computer Systems, WordPerfect, Database Courses, School of Computer Studies, Khartoum, Sudan 1988.

3. language:

Arabic, English and Danish.

4. Working experience:

4.1 Current Post:

2002-Till now: Associate professor: Head of the Department of Medical Parasitology and Entomology at the Institute of Endemic Diseases, University of Khartoum, Sudan.

Elected Member of the scientific committee of African Malaria Network Trust (AMNET).

Member of the Sudanese Society for Tropical Medicine, Sudan.

Member of  the Council of The Institute of Endemic Disease(IEND).

Member of the Council of the Faculty of Laboratory Technology, University of Khartoum.

Member of The scientific Committee at IEND and faculty of Laboratory Technology, University of Khartoum.

Treasurer of The   Sudanese- Norwegian Friendship Association.

Member of the International Club, Khartoum.

4.2 Pervious posts:

1997-2001: Assistant Professor, Head of Department of Parasitology and Medical Entomology at the Institute of Endemic Diseases, University of Khartoum, Sudan.

1988-1997: Senior Parasitologist, Malaria Administration, and Ministry of Health, Khartoum, Sudan.

4.3 Major achievements:

  • Establishment of the Department of Medical Parasitology and Entomology at the Institute of Endemic Diseases.

  • Head of Malaria Research Group, at IEND University of Khartoum.

  • Establishment of Parasitology Research laboratory, University of Khartoum.

  • Establishment of Parasitology Department at malaria Administration, Ministry of Health.

  • Coordination and organization of a number of workshops and Short training programs at IEND.

  • Establishment of DANIDA Laboratory at the Department of Biochemistry, University of Khartoum.

  • Co-ordinating and teaching in malaria training courses held for different personnel Categories. These courses were held at the Malaria Training Centre, Sennar, Sudan and Khartoum H.Q.

  • Supervision and establishment of malaria laboratories in different parts of the Sudan.

  • Participated in the annual planning and implementation of malaria control programmes in Sudan and production of annual reports during that period.

  • Participated in the preparation of plan of action for malaria control in 3 regions in Sudan, these programmes were supported by the World Bank, African Development Bank and Japanese Development Agency (1989-90).

5. Research and Projects Awards: 

  • Ph. D DNIDA  Fellowship, Denmark. 1991-1995.

  • The role of strain specific immunity in the development of strain specific immunity (Tropical Medicine Award, The Wellcome Trust Fellowship, UK) 1998-2001 (PI) (Successfully completed). 

  • The role of antigenic variation in maintenance of asymptomatic malaria infections throughout the Sudanese dry season 1998-2001 (TDR/WHO) (PI) (Successfully completed).

  • Natural History of PKDL and it is role in transmission TDR/WHO2 1999-2004 (PI) successfully completed.

  • Bio Mal Par  Project (Investigator) (EU) 2004-2006

  • Epidemiological study of malaria in areas of seasonal malaria transmission in Ethiopia and Sudan (WHO/TDR MIM) (PI) 2004-2007.

  • Ministry of Higher Education Research Fund 2004.

 

6. Teaching experience:

6.1 Undergraduate training:

  • Teaching Medical Parasitology and Immunology courses at the Institute of Endemic Diseases, laboratory Technology College, and Faculty of Health University of Khartoum in addition to the following universities:

  • Faculty of Science & Technology, Elnileen University, Khartoum.

  • Faculty of Medicine Shandi University, Northern State.

  • Faculty of Medicine, Bakhet Elruda University, White Nile State.

  • Faculty of Medical Laboratory, Omdurman Ahlia, University, Khartoum.

6.2 Postgraduate training

Teaching Parasitology courses to M Sc. and M Sc. Qualifying students at the Institute of Endemic Diseases.

Supervised the following Ph. D, M Sc. & MD students, University of Khartoum:

  • Miss Gamila Ibrahim Ahmed Gad Allah, Ph. D Degree, University of Khartoum.

  • Thesis title: humoral immune response to P. falciparum antigens in population living in seasonal and unstable malaria transmission area (eastern Sudan).

  • MRs: Rose Ajake, MD, University of Khartoum.

  • Thesis title: Role of Tumor necrosis factor Alpha (TNF) in severe malaria among children admitted to Khartoum children’s Emergency Hospital.

  • Shadin AbedElgaffar AbedlRahim, M. Sc Degree, University of Khartoum

  • Thesis title: Exposure to Plasmodium falciparum parasites outside the malaria season in an area characterized by seasonal & unstable malaria transmission in eastern Sudan).

  • Miss. Muna Amohamed Atta Elmanan, M. Sc Degree, University of Khartoum

  • Thesis title: Genetic Diversity in development of Immunity to malaria.

  • Miss. Limya Elhag Yousif Ahmed, M. Sc Degree, University of Khartoum

  • Thesis title: Immuno-epidemiological studies of malaria in Rahad River area eastern, Sudan.

  • Mrs. Dalal Kamal Eldin Diab, M. Sc. Degree, University of Khartoum

  • Thesis title:characterization of malaria related anaemia in eastern Sudan.

  • Miss. Nuha Mohamed Yousif Ismail, M. Sc Degree, University of Khartoum

  • Thesis title: Humoral immune responses to the Glucose-regulated Protein 78-a novel Leish Miss. Tayseer Abdelhady Mohammed Yousif  ( M Sc Molecular Biology malaria)

  • Mr. Mushal Allam Mohamed Al-Haj Ali   (M Sc Molecular Biology malaria)

  • mania donovani antigen.

  • Miss. Sara Basher Taha Mohammed  Immunology( M Sc Molecular Biology malaria)

  • Miss. Tayseer Abdelhady Mohammed Yousif  ( M Sc Molecular Biology malaria)

  • Ms Amel salih Awad (M Sc Parasitology)

Current Students:

Ph. D Students:

  • Mr Meshashe Balkew, University of Addis Ababa.

  • Mr. Mansour Mmohamed Mansour, University of Sudan

Current M Sc Students:

  • Mr. Omer Mahgoub Hassan Dirar ( M Sc Molecular Biology )
  • Miss Reem Birum (M Sc Immunology)
  • Miss Wegdan AzrgSc Molecular Biology)
  • Miss Badria Elsyed (Molecular Biology
  • Miss Soha Idrous (M Sc Immunology)
  • Mr. Mohamed Mohi Eldin( M Sc Immunology)

 

7 Conferences and Meetings:

7.1 Presented papers or abstracts at the following meetings:

  • First Annual BiomalPar Conference on the Biology of the malaria, March 2-4 2005 Heidelberg (Germany)

  • The Global forum for Bioethics meeting, 17th-19th March 2005 Blantyre, Malawi.

  • Epidemiology of Malaria in areas characterized by seasonal and unstable malaria transmission, African Health Sciences Congress(AHSC), 29-30 Sept. 2003, Addis Ababa, Ethiopia.

  • The current Situation of malaria in Sudan, and potential malaria vaccine trial, Regional Scientific meeting of malaria vaccine Researchers, Maputo, Mozambique 10-11 November 2003.

  • Genetic Characterization of P. falciparum malaria infections in 2 successive years in area characterized by seasonal and unstable malaria transmission in Sudan. MIM Meeting Arusha, Tanzania 2002.

  • Immuno-epidemiological studies of humoral immune response to P. falciparum antigens in an area characterized by seasonal and unstable malaria transmission in Sudan. MIM African Conference 14-19 March 1999. Durban, South Africa.

  • Malaria infection, morbidity and genetic diversity  in Sudan, The 2nd  African malaria vaccine testing network meeting,  22nd –25th  February 1998 Accra Gahanna.

  • Humoral immune responses to Plasmodium falciparum antigens CSP protein, Pf155/RES, IFA and Gulamate Rich Protein in area characterized by seasonal and unstable malaria transmission in the Sudan, Malaria research in Denmark meeting 1st-2nd December 1998, Copenhagen, Denmark.

  • Immunity to malaria under low and unstable transmission, the Pathogenesis Committee, World Heath Organisation meeting 22nd September 1997 Wood Hole, USA.

  • Recent situation of malaria in the Sudan and the feasibility of vaccine trials in the country, The 1st African malaria vaccine testing network meeting, 24th –26th February 1995, Arusha Tanzania.

  • Evidence of high of high proportion of asymptomatic malaria infections in seasonal and unstable malaria transmission area in Sudan. European Conference on Tropical Medicine, 22nd-26th October 1995 Hamburg, Germany

  • Blood stage P. falciparum infections frequently remain sub-clinical in an area of seasonal and unstable malaria transmission in Sudan, Department of Genetics, Institute of Cell, Animal, and Population Biology 25th August 1994, Edinburgh Scotland.

  • Humoral immune responses to Plasmodium falciparum antigens CSP protein, Pf155/RES, IFA and Gulamate Rich Protein in area characterized by seasonal and unstable malaria transmission in the Sudan, Malaria research in Denmark meeting 1st-2nd December 1998, Copenhagen, Denmark.

  • Is immunity against malaria acquired by individuals living in eastern Sudan, Malaria and Leishmania meeting, Sudanese Society of Tropical Medicine and Hygiene10th –11th September 1994, Khartoum, Sudan?

  • Antibodies to P. falciparum antigens as markers of seasonal variation in exposure to malaria parasites. 6th Malaria meeting of the British Society for Parasitology, 19th-21st 1994 Liverpool, U.K.

  • Protection against clinical P. falciparum malaria in residents from an area of seasonal and unstable malaria transmission in Sudan. ICOPA X11, 10th –14th October1994 Azmir Turkey.

  • Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-selectin) during acute P. falciparum malaria. Scandinavian Society of Immunology 24th annual meeting, 22nd -26th May 1993, Arhus, Denmark.

7.2 Participated in the following meetings and workshops: 

  • The 2nd International Mini-Symposium: Adhesion and Cytokines and Adhesion molecules in cerebral malaria, 11th August 1992, Copenhagen, Denmark.

  • Symposium on Parasites and the Allergic Inflammation, Danish Society for Parasitology, 6th February 1993, Copenhagen, Denmark.

  • Malaria Control Workshop 27th –29th January 1993. Khartoum, Sudan.

  • Participated in Scandinavian Society for immunology, XXVIth annual meeting and XIth Summer school. 24-28th May 1995 Goteborg, Sweden.

  • Participated in the 7th Malaria meeting of the British Society for Parasitology, 19-22nd September 1995, London. U.K.

  • Sudanese, Danish and Scottish malaria meeting. 10th April 1996, Molle, Sweden.

  • The third residential meeting of the Royal Society of Tropical Medicine and Hygiene, 18 20th September 1996, Cambridge U.K.

  • Malaria in Africa: Challenges for cooperation 6th –9th January 1997, Dakar, Senegal.

  • Surviving in Science workshop, for Wellcome Trust International Fellows, 16th -18th July 1998, London, and U.K.

  • Malaria Gordon Conference, Somerville College, 26th July –1st August 1998, Oxford, U.K.

  • The 10th Malaria meeting of the British Society for Parasitology, 21st-23rd September 1998, Edinburgh, Scotland.

Coordinated and organized the following international

  • Heath system and health Research in conflict Areas workshop 28-30th July 2005, Khartoum Sudan.

  • Workshop on Health research Ethics and good Clinical practice, 5-11 Jan 2003, Khartoum, Sudan.

  • Malaria Immunology from Field to bench international Course, Addis Ababa 6-13 October 2005.

8. Publications:

 

 

1.       ELhassan I. M (1986) Schistosoma mansoni: Infectivity of cercariae by cutaneous and oral routes.  M.Sc. Dissertation August 1988 (Liverpool of Tropical Medicine, UK).

2.       Saeed BO, Hassabalrasoul MA, Ibrahim KE, Salih SA, Elhassan I.M, Kider S, and Bayoumi RA. (1990). Plasma chloroquine measurement in the evaluation of Plasmodium falciparum sensitivity.  J.Trop.Med.Hyg.  93: 393-396.

3.      Ibrahim ME, Elhassan IM, Elmoubark EA and Awad-Karim FM(1991) A case of P. falciparum malaria sensitive to chloroquine but resistant to  pyrimethamine/ sulfadoxine in Sennar, Sudan, Trans. R. Soc. Trop. Med. Hyg. 85: 446-447

4.      Elhassan IM, Satti G.M.H, Abed-Elkariem A., Fadul I., Elkhalifa A.A, Abedelrahim A.M, Ming C. and Theander T.G. (1993), The efficacy of artemether in the treatment of P.  falciparum malaria in the Sudan. Trans. R. Soc. Trop. Med. Hyg. 87: 685-686.

5.      Hviid L., Theander TG, Elhassan I. M, Jansen J.B (1993) Increased plasma levels of soluble ICAM-1 and ELAM-1 (E-Selectin) during acute  P. falciparum malaria, Immunology letters, 36(1993) 51-58

6.      Hviid L., Elhassan I. M, Dodoo D., Jansen J.B, Bygbjerg I.C, Satti G.M.H, Theander T.G. (1994), Differential T-cell expression of LFA-1 in residents from Africa and Denmark. Description of the phenomenon and its possible basis. Immunol Lett 39: 147-151.

7.      Elhassan I. M, Hviid L., Satti G.M.H, B. Åkerstrom, Jakobsen P.H, Jansen J.B and Theander T. (1994), Plasma markers in P. falciparum: Evidence of endothelial inflammation, T cell activation, T-cell reallocation during uncomplicated disease episodes. Am. J. Trop. Med. Hyg. 51: 372-379.

8.      Jakobsen P.H, Jansen, Morris-Jones, Rønn. A, Hviid L., Theander T.G, Elhassan I.M, Bygbjerg I.C, and Greenwood BM., (1994), Increased plasma concentrations of sICAM, sVCAM-1, and sELAM-1 in patients with P. falciparum or P. vivax malaria and association with disease severity.Immunology.83 665-669.

9.      Elhassan I. M, Hviid L., Arnot E.D, Roper C. and Theander G.T. (1995), Is immunity against P. falciparum malaria acquired by individuals living in seasonal and unstable malaria transmission area? Sud. Med. J.:33(1) 101-104.

10.  Elhassan I. M, Hviid L., Jakobsen P.H, Giha H, Satti G.M.H, Arnot E.D, Jansen J.B and Theander G.T. (1995). Antibodies to Plasmodium falciparum antigens as markers of seasonal variation in exposure to malaria parasites. Abstract Ann Trop. Med. Parasitology 89: 189,

11.  Roper C., Elhassan I.M, G Satti, AA sultan, S Keys, HA Babiker, D.E. (1995), Malaria transmission and the Ro value question. A PCR based approach. Sudan. Med. J.:33(1) 31-39.

12.  Elhassan I. M (1995) Immunol-epiemiological studies of P. falciparum malaria in easter sudan, Ph. D thesis University of Copenhagen, Denmark.

13.  Elhassan I. M, Hviid L., Jakobsen P.H, Geha H., Satti G, Arnot E.D, Jansen J.B, and Theander G.T. (1996), High proportion of sub clinical P. falciparum malaria infection in an area of seasonal and unstable malaria transmission in Sudan Am. J. Trop. Med. Hyg.   53;78-83.

14.  Hviid L, Elhassan IM, Jakobsen PH, Abu-Zeid YA, Jensen JB, Theander TG. The cause of in vitro non-responsiveness of peripheral T cells from acut P. falciparum malaria patients. Studies from Eastern Sudan.  Sud.Med.J. 1995;33:145-149.

15.  Roper C., Elhassan I. M, Hviid L, Giha H., Satti G., Richardson W., Theander T.G and Arnot D.E., (1996), Detection of a very low P. falciparum parasitaemia by nested Polymerase chain reaction and the reassessment of the epidemiology of unstable malaria in Sudan. Am. J. Trop. Med. Hyg.   54;325-331.

16.  Roper C., Richardson W,  Elhassan I. M, H. Giha, Hviid L, Satti G., Theander T.G and Arnot D.E. (1998) Seasonal change in P. falcipaum population in individuals and their relationship to clinical malaria: a longitudinal study in a Sudanese village.  Parasitology 116, 501-510).

17.  Staalsø T, Khalil E. A, Elhassan I. M, Zijlstra E. E, Elhassan A. M, Giha H, Theander T. G, and Jakobsen P .H, (1998), Antibody reactivity to conserved linear epitopes of P.  falciparum erythrocyte membrane protein 1. Immunology letter  60: 121-126.

18.  Giha, H. A., Theander, T. G., Staalsø, T., Roper, C., Elhassan, I. M., Babiker, H., Satti, G. M.  H., Arnot, D. E. & Hviid. L. (1998). Seasonal variation in agglutination of P  falciparum -infected erythrocytes. American Journal of Tropical Medicine Hygiene 58, 399-405.

19.  Cavanagh D.R, Elhassan I. M, Roper C, Robinson VJ, Giha H, Holder A.A, Hviid L, Theander T.G, Arnot D.E, and McBride J. S (1999) A longitudinal study of type specific antibody response to P. falciparum: merozoite surface protein-1 in an area of unstable malaria in Sudan, J. Immunology 161: 347-359.

20.  Giha H A,  Staalsoe T, Dodoo D , Elhassan I. M,  C. Roper, Satti G, Arnot D. E, Hviid L and  Theander T.G (1999)  Overlapping antigenic repertoires of variant antigens expressed on the surface of infected erythrocytes by P.  falciparum,  Parasitol, 119. 7-17.

21.  Giha H.A, Staalsoe T, Dodoo D, Elhassan I.M, Roper C, Satti G.M.H, , Arnot D.E, Theander T.G, Hviid L. (1999). Nine year Longitudinal study of antibodies to variant antigens on the surface of P. falciparum-infected erythrocytes Infection and Immunity 67: 4092-4098.

22.  Funjungo P. N., Elhassan I.M, Cavanagh D.R, Theander T.G, Hviid L, Roper C,   Arnot D.E, and McBride J.S (1999)  A Longitudinal study  of human antibody responses to P.  falciparum Rhoptry-associated protein 1 in a region of seasonal and unstable malaria transmission. Infections and immunity 67:2975-2985.

23.  Hamad AA, El Hassan IM, Ahmed GI, El Khalifa AA, Abdelrahim SA, Theander TG and Arnot D. Chronic P .falciparum infections in an area of low intensity malaria transmission in the Sudan. Parasitology 120: 447-456, 2000

24.  Cavanagh D.R, Dobano-Lazaro, Marsh K, Elhassan I. M, A. M Elhassan, Khalil E. A, , Theander T.G, Arnot D.E, and McBride J.S (2001) Differential patterns of Human IgG subclass responses to distinct regions of merozoite surface protein 1 (MSP-1) of P. falciparum, infection and immunity (2001).

25.  Staalose T., Hamad AA, Hviid L., El Hassan IM, Arnot D, and Theander TG. (2002). In vivo switching between variant surface antigens in human P. falciparum malaria Journal of infectious diseases 186:719-722.

26.  AM Musa ; EAG Khalil ; MA A/Raheem ; EE Zijlstra ; ME Ibrahim ; IM Elhassan ; MM Mukhtar  & AM EL Hassan. (2002), Natural History of Sudanese Post Kala-azar Dermal Leishmaniasis: Clinical, Immunological & prognostic  features., Annuals of Trop. Med & Pparasitology vol. 96, 765-772.

27.  EE Zijlstra, A Musa, EAG Khalil, IM El Hassan, and AM El-Hassan, (2003) Post-kal-Azar Dermal Leishmaniasis(PKDL) The Lancet infectious Diseases V: 3  87- 98.

28.  Musa AM; Khalil EAG; Ismail A; Elhassan IM; Fesharki H; Khamesipour A; Modabber F, Zijlstra EE; & El-Hassan AM (2004). Safety, immunogenicity  and possible efficacy of Immunochemotherapy of persistent post kala-azar dermal leishmaniasis (PKDL) Annuals of Trop. Med & Pparasitology (submitted).

  1. EAG Khalil; Nahla B. Ayed; AM Musa; Ibrahim ME; Mukhtar MM; Zijlstra EE; Elhassan IM; P.G.Smith; PM. Kieny; Ghalib HW; F.Zicker; Modabber F; Elhassan AM (2006)  Dichotomy of protective cellular immune responses to human visceral leishmaniasis. J of clinical and Experiential Medicine (in press).
  2. Ismail, E.A.G. Khalil, A.M. Musa, I.M. EL Hassan, M.E. Ibrahim, T.G. Theander and A.M. EL Hassan (2006) The pathogenesis of post kala-azar dermal leishmaniasis from the field to the molecule: Does ultraviolet light (UVB) radiation play a role? Medical Hypotheses, In Press.
  3. Ismail, E.A.G. Khalil, A.M. Musa, I.M. EL Hassan, M.E. Ibrahim, T.G. Theander and A.M. EL Hassan (2007) The immunopathogenesis of post kala-azar dermal leishmaniasis (PKDL) (submitted).

 

9. Refrences

Dr. Marita Tryoye-Blomberg,

Department of Immunology

Stockholm University

S-106 91 Stockholm

Sweeden

E mail: marita@imun.su.se

 

Professor Riad Bayoumi

Department of Biochemistry

College of Medicine

Sultan gabous University

P. O Box 35

Al-khod

P. C 123

Eamail : bayoumi@omantel.net.om

 

Professor T. G. Theander

Centre for Medical parasitology

University of Copenhagen

Denmark

Email:  Theander@cmp.dk

 

10. Contact Address:

Ibrahim Mohamed  Elhassan,

Department of Parasitology

Institute of Endemic Diseases

University of Khartoum

P. O Box 1739

Khartoum

Sudan

E mail: Ibrahimelhassan@iend.org

Phone: (0024911) 79 32 64

Cellular Phone:249912131303