Department of Molecular Biology, Institute of Endemic Diseases,

University of Khartoum. Medical Campus, Qasser Street,

P.O.Box 102 Khartoum Sudan

Phone /Fax :249 83 793263

e-mail mibrahim@iend.org

• Elementary, Intermediate and secondary schools

• B. Sc. Zoology and chemistry, University of Zagazig.

• Diploma in Medical Entomology & Parasitology Cairo University.

• M.Sc. in Zoology, University of Khartoum.

• Course in Immunology and Molecular Biology, Liverpool School of Tropical Medicine, UK 

1991-1994

• PhD entitled  Identification and Genetic characterization of Leishmania parasite from the current outbreaks of visceral and cutaneous leishmaniasis in the Sudan. Faculty of Health Science University of Copenhagen Denmark.

• Course on Computer method in molecular biology.  International Centre of Genetic Engineering and Biotechnology (ICGEB), Trieste Italy.

• Course on human genome diversity (ICGEB) Trieste Italy.

• Workshop on ethics in health research in Africa, Khartoum.

• 2006- Professor Of Molecular Biology, Institute of Endemic Diseases, University of Khartoum.

• 2002-2006 Associate Professor and  Head Department of Molecular Biology, Institute of Endemic Diseases, University of Khartoum.

• 1997 -2002 Assistant Professor, Institute of Endemic Diseases, University of Khartoum.

• 1997-1998 Wellcome Visiting Research Fellow, Department of Pathology, University of Cambridge,

• Affiliated to Christ college, University of Cambridge (Dining rights).

• 1983-1997 Research Scientist, National Health Laboratory Sudan. .

• Council of college of post graduate studies, Uof K, 1999-

• Neglected Diseases Group, ) A network of experts that help the DNDi (neglected diseases initiative) addresses the crisis in R&D in neglected  diseases 2003.

• Editorial board of the Journal of Genomics & African Society  (Cape Town) 2004.

•  Editorial board of the Journal of Molecular and Genetic Medicine (Oxford).

• Council of Scientific Advisors (CSA) of the International Center for Genetic Engineering and Biotechnology 2004.

• Sudanese National Academy of Science (elected General secretary 2005-)

• Royal Society of Tropical Medicine and Hygiene, UK

• Sennate, University of Khartoum 2000-

SCIENTIFIC PUBLICATIONS IN PEER REVIEWED JOURNALS (last twelve years) :

• Ibrahim ME, Smyth AJ, Ali MH, Barker DC, Khrazmi A (1994). The polymerase chain reaction  can reveal the occurrence of naturally mixed infection with Lishmania parasite Acta Tropica, 57: 327-332.

• Ibrahim ME, Hag- Ali M, El Hassan AM, Ttheander TG, Kharazmi A (1994). Leishmania resistant of sodium stibogluconatte: drug associated macrophage dependent killing. Parasitology Research, 80:569 574.

• Seielsted MT, Harbet JM, Lin AA, Underhill P, Ibrahim ME, Vollarth, Cavalli-Sforza LL (1994) Constructing of humanY-chromosomal Haployeps using a new polymorophic A to G transition. Human Molecular Genetics, 3 (12) : 2159-2161.

• Ibrahim ME,  Evans DE, Theander TG, El Hassan M, Kharazmi A. (1995)

  Diversity among Leishmania isolates from the Sudan, isoenzyme homogeneity of L.donovani versus heterogeneity of L.major. Transactions of Royal Society of Tropical  Medicine and Hygiene, 89.370-371.

• Andresen K, Ibrahim ME, Theander TG, Kharazmi A (1996) Random amplified polymorphic DNA for the differentiation of Leishmania donovani isolates from Sudan. Trans R Soc Trop Med Hyg, 90, 204-205. 

• Ibrahim ME (1996) The changing face of leishmaniasis in Sudan: a molecular biology perspective.(Abstract) Trans R Soc Trop Med Hyg, 90,  

• Ibrahim ME, Suliman A, Hashim FA, Khalil EAG, Evans DA, Kharazmi A, ELHassan AM.(1997) Oro-nasal leishmaniasis coused by a parasite of an unusual isoenzyme profile. American Journal of Tropical Medicine and Hygiene: 56: 96-98.

• Seielstad M, Bekele E, Ibrahim M, Toure A, and Traore M (1999) Y chromosome microsattelite diversity and a recent African origin for modern humans, Genome Resaerch.

• AM, Khalil E.A.G.,  Elsheikh EA, Zijlstra EE, Osman A. & Ibrahim ME. (1998).  Post Kala-azar ocular leishmaniasis.  Transaction of the Royal Society of Tropical Medicine & Hygiene, 92:177-179.

• Khalil E.A.G., Elhassan AM, Zijlstra EE, Hashim FA, Ibrahim ME, Ghalib HW & Ali MS. (1998).  Treatment of visceral leishmaniasis with sodium stibogluconate in Sudan: management of those who do not respond.  Annals of Tropical Medicine & Parasitology. 92(2): 151-158.

• Seielstad M, Bekele E, Ibrahim M, Toure A, and Traore M (1999) Y chromosome microsattelite diversity and a recent African origin for modern humans, Genome Resaerch, 9,  558-67.

• Ibrahim ME,  Lambson B,  Osman A,  Daifalla N, Yousif H, Al Naeem DA, Khalil EAG, Kadaru A, Ghalib HW,  Barker DC, El Hassan AM (1999) Kala-azar in a high transmission foci: An ethnic and geographical dimension.. Am J Trop Med Hyg, 61,941-944.

• Underhill, P.A., Shen, P., Lin, A.A., Passarino, G., Yang, W.H., Kauffman, E., Bonne-Tamir, B., Bertranpetit, J., Francalacci, P., Ibrahim, M., Jenkins, T., Kidd, J.R., Mehdi, S.Q., Seielstad, M.T., Wells, R.S., Piazza,A., Davis, R.W., Feldman, M.W., Cavalli-Sfroza, L.L., and Oefner, P,J. 2000. Y chromosome sequence variation and the history of human populations. Nature Genet.26:358-361.

• Khalil EAG, Elsiddig, KE, Elsafi MEMO, El-Hag, Elkhidir IM, Suleiman G, Hussein AM, Ibrahim ME. & Elhassan A.M (2000). Supra-sternal tuberculous abscess: a report of three cases; Medicine and Hygiene 94:1-3.

• Khalil EA, El Hassan AM , Zijlstra EE, Mukhtar MM, Ghalib HW, Musa B, Ibrahim ME, Kamil AA, Elsheikh M, Babiker A, Modabber F.(2000) Autoclaved Leishmania major vaccine for prevention of visceral leishmaniasis: a randomized, double-blind, BCG-controlled trial in Sudan, Lancet. 356 (9241):1565-9.

• Ibrahim ME and DC Barker (2001) The origin and evolution of The Leishmania donovani complex as inferred from a mitochondrial cytochrome oxidase II gene sequence Infection Genetics and Evolution, 1, 61-68.  

•  Blackwell JM, Goswami T, Evans CA, Sibthorpe D, Papo N, White JK, Searle S, Miller EN, Peacock CS, Mohammed H, Ibrahim M. SLC11A1 (formerly NRAMP1) and disease resistance. Cell Microbiol 2001 Dec;3(12):773-84.

• Masri MA,  Abdel Seed NM, Fahal AH , Romano M3, Baralle F, El Hassan AM and Ibrahim ME.(2002) Minor Role for BRCA2 (exon11) and p53 (Exon 5-9) among Sudanese breast cancer patients. Breast Cancer Research and Breast Cancer Res Treat 2002 Jan;71(2):145-7.

• ME Ibrahim: The epidemiology of visceral leishmaniasis in east Africa: hints and molecular revelations. In Molecular Epidemiology of Parasitic diseases. Edited by J Alvar and DC Barker Trans R Soc Trop Med Hyg 2002 Apr;96 Suppl 1:S25

• Fadl-Elmula I, Kytola S, Leithy ME, Abdel-Hameed M, Mandahl N, Elagib A, Ibrahim M, Larsson C, Heim S (2002).Chromosomal aberrations in benign and malignant bilharzia-associated bladder lesions analyzed by comparative genomic hybridization. BMC Cancer . 22;2(1):5

• Bereir REH1, Mohamed HS1,3, Seleistad M, El Hassan AM1, Khalil EAG1,

  Peacock  CS3, Blackwell JM3, Ibrahim ME. (2003) Allele frequency and genotype distribution of polymorphisms within disease-related genes in is influenced by  ethnic population sub-structuring. Genetica 119(1):57-63.

• Mohamed Hiba S , Muntaser E. Ibrahim, E. Nancy Miller, Christopher S.
  Peacock, Eltahirk A. G. Khalil, Heather J. Cordell, Joanna M. M. Howson,
  A. M. El Hassan, Rihab E.H. Bereir and Jenefer M. Blackwell (2003) Genetic susceptibility to visceral leishmaniasis in The Sudan: Linkage and association with IL4 and IFNGR1. Genes and Immunity. 4, 351-355.

• Kamil AA, Khalil EA, Musa AM, Modabber F, Mukhtar MM, Ibrahim ME,

  Zijlstra EE, Sacks D, Smith PG, Zicker F, El-Hassan AM.(2003). Alum-precipitated autoclaved Leishmania major plus bacille Calmette-Guerrin, a candidate vaccine for visceral leishmaniasis: safety, skin-delayed type hypersensitivity response and dose finding in healthy volunteers. Trans R Soc Trop Med Hyg.  97(3):365-8.

• Aljafari AS, Khalil EA, Elsiddig KE, El Hag IA, Ibrahim ME, Elsafi ME, Hussein AM, Elkhidir IM, Sulaiman GS, Elhassan AM (2004) Diagnosis of tuberculous lymphadenitis by FNAC, microbiological methods and PCR: a comparative study. Cytopathology. 15(1):44-8.

• Mohamed HS, Ibrahim ME, Miller EN, White JK, Cordell HJ, Howson JMM, Peacock CS, Khalil EAG, Elhassan AM, Blackwell JM (2004) SLC11A1 (formerly NRAMP1) and susceptibility to visceral leishmaniasis in the Sudan. European Journal of Human Genetics. 12(1):66-74.

• Blackwell, J.M., Mohamed, H.S. and Ibrahim, M.E. (2004) Genetics and  

   visceral leishmaniasis in The Sudan.  Trends in Parasitology, 20(6):268-74.

• Mahdi M, Elamin EM, Melville SE, Musa AM, Blackwell JM, Mukhtar MM,Elhassan AM, Ibrahim ME (2004)Sudanese mucosal leishmaniasis: isolation of  a parasite within the Leishmania donovani complex that differs genotypically from L. donovani causing classical visceral leishmaniasis. Infect Genet Evol. 2005 Jan;5(1):29-33.

• Khalil EA, Ayed NB, Musa AM, Ibrahim ME, Mukhtar MM, Zijlstra EE, Elhassan IM, Smith PG, Kieny PM, Ghalib HW, Zicker F, Modabber F,         Elhassan (2005) AM Dichotomy of protective cellular immune responses to human visceral leishmaniasis. Clin Exp Immunol. 140(2):349-53.

• Elamin EM, Guerbouj S, Musa AM, Guizani I, Khalil EA, Mukhtar MM, Elkadaro  AM, Mohamed, HS, Ibrahim ME, Abdel Hamid MM, El Azhari M, El Hassan AM (2005). Uncommon clinical presentations of cutaneous Leishmaniasis in Sudan. Trans RSocTropMedHyg.99(11):803-8

• Alleithi M,Gisselsen D, Neilsen T, Alagib A, Ibrahim ME, Fadl-Elmula I  (2006) Deeletion (X)(p11) carrying SRY sequences in a sudanese infant with  ambigous genetalia. BMC Pediatr. 4;6:11.

• Ismail A, Khalil EA, Musa AM, El Hassan IM, Ibrahim ME, Theander TG, El Hassan AM ( 2006) The pathogenesis of post kala-azar dermal leishmaniasis from the field to the molecule: does ultraviolet light (UVB) radiation play a role? Med Hypotheses. 66(5):993-9.

• Mohammed AO, Attalla B, Bashir FMK, Ahmed FE,  Elhassan AM, Ibnauf  G, Jiang W, Cavali-sforza L.L, Karrar Z. Ibrahim ME (2006) the relationship of  the sickle cell gene  to the ethnic and geographic groups populating the sudan. Community Genetics. 9(2):113-20.

• Nawal Tagelsir, Abdelraheem ZA,  Medani A,  Salih O,   Hamad A, Giha H, El-Agib A, Khan B, Saeed NS, Ibrahim ME (2006) High frequency of Plasmodium falciparum PfCRT K76T and Pfpgh N86Y in patients who clear after Chloroquine treatment in the Sudan. Acta Tropica. 97(1):19-25.

• Sharief AH, Gasim Khalil EA, Theander TG, Kharazmi A, Omer SA, Ibrahim ME (2006) Leishmania donovani: An in vitro study of antimony-resistant  amphotericin B-sensitive isolates. Exp Parasitol. Upub ahead of print.

• Mohamed A. Salih, Muntaser E. Ibrahim, Jenefer M. Blackwell, E. Nancy Miller, Eltahir A. G. Khalil, Ahmed M. ElHassan, Ahmed M. Musa and Hiba S. Mohamed IFNG and IFNGR1 gene polymorphisms and susceptibility to post kala-azar dermal leishmaniasis in Sudan. Genes and Immunity (In press).

• Sarah A. Tishkoff, Floyed A.Reed, Alessia Ranciaro, Benjamin F. Voight,     Courtney C.Babbit, Jesse S. Silverman, Kweli Powell, Holly Mortensen, Jibril. B.   Hirbo,  Maha Osman, Muntaser Ibrahim, Sabah A. Omar, Jilur Ghori, Suzannah   Bumpstead, Jonathan K. Pritchard, Gregory A. Wary, Panos Delouckas(2006)   Convergent adaptation in humans: the genetic basis of lactase persistence in  Africa. Nature Genetics (in press).

• Miller N, Fadl M, Mohamed HS,  Elzein A, Jamieson, Cordell, Peacock, Fakiola,Khalil EAG, Elhassan AM, Musa, Ibrahim ME, Blackwell JM (Submitted) Y   chromosome lineages tagvillage specific genes on chromosomes 1p22 an 6q27 that control leishmaniasis in the Sudan.

• Nevein A Salih, Ibrahim Almugtaba, Abeir Elzein, Ayman Hussein, Ibrahim M Elhassan, Eltahir AG Khalil, Hani Ishag, Hiba Salah, Dominic Kwiatkowski,Muntaser Ibrahim Loss of Balancing Selection in the βS, Globin Locus in a nonpanmictic African population (submitted) .

• Populations of the Sudan, a Genetic Perspective in retrospect. 2nd  meeting on the Genetics of the Population of The Sudan and East Africa 2002.

• The Genetics of Ethnicity and Disease, Medical Genetics in the developing World, Course at the ICGEB Trieste Italy 2003.

• Molecular Diagnostics and therapeuatics a viable case for Africa 1st World Biotechnology Forum 2-5 March Concepcion Chile 2004 (invited speaker).

• Health Genes and Culture from an African popultion perspective,  2nd Annual Africa Genome Conference. Cairo,March 2004.  

• Genotypic and phenotypic correlates of susceptibility to malaria in two populations of different ethnic origins in eastern Sdaun BioMalrPar Heidelberg  2-4 March 2005.

• Visceral leishmaniasis in the Sudan: a centanary of a serial killer. Brazilian Society of  Protozology, Coxambu 7-10 Nov 2005 (key Note speaker)  .

• Genetic diversity and disease, What could be learnt from the Y chromsome. 4th Annual conference of the African Society of Human Genetics. Addis Ababa June 2006.

  Coordinator and coorganizor of several courses and workshops localy, regionally and internationally. Now the coordinator of the Diploma/M.Sc. degree in Molecular Medicne offered by the graduate colleage of the University of Khartoum and coorganizor of the annual Khartoum Winter School of Bioinformatics and Staistical Genetics (past two years)

•  M E Ibrahim and AM Elhassan “Sudan”Pocket Guide to Cultural Health  Assessment, third edition Edited By Carolyn E. D’Avanzo, RN, DNSc. Elseveir.

• Dissecting The Racial mind, Assays on race and Science (inpress) .

• Translations: The Great Human Dispaoras, The history of human genetic diversity and evolution, By LL.Cavalli-Sforza (to Arabic)

• Study of endemic non-infectious and infectious diseases in relation to the population genetics and human genome diversity in  Sudan, including the role of disease in shaping the current ethno-geographical picture of the area

• Screening for known polymorphisms that underlies particular disease phenotypes,  employing an integrated approach towards understanding the relationship of mankind to disease, which takes into consideration the evolutionary aspects in the relations of microbes and Man as well as the complex biological-cultural nature of human evolution. The main set of information generated in the center of disease and diversity is related to the genetic polymorphism in Homo sapiens and their most common pathogens as well as disease vectors.

TEACHING EXPERIENCE

• Teaching Molecular Biology and Genetics to pre masters classes in the Institute of Endemic Diseases U of K.

• Teaching molecular genetics to the Part I students of the diploma of Paediatrics, Medicine, and Pathology.

• Co-ordination and organisation of the molecular biology course on the application of molecular biology tools to the study of infectious diseases entitled: molecular biology techniques in research and diagnosis of infectious diseases the last one sponsored by ICGEB (Feb 1998- Khartoum Sudan).

• Faculty in an ICGEB courses entitled “Medical Genetics for Developing countries”(2003).

• Amna O Hahim: Characterization of Leishmania donovani from endemic area using the polymerase chain reaction. (1997)

• Hind M Abushama: Inter and intra population diversity of Anopheles arabiensis in Khartoum state as revealed by polymorphic molecular markers. (1999)

• Nahla M Ali Osman: Molecular features of the Leishmania donovani cell cycle.(1999)

• Mei A Masri: Mutational analysis of brca2 and p53 genes in a panel of sudanese breast cancer patients (2001)

• Nahid A H Gornas Mutational analysis of the conserved portion of p53 Tumor supressor gene among sudanese oral and esophageal cencer patients.(2000)

• BaderAldin AlAmin: A study on 4 selected sudanese populations based on 6 polymorphic microsatellite markers (2002)

• Nazar M Abdalla: Immunological and molecular studies on leishmaniasis in the Nuba mountains. (ph.D) (1999)

• Muzamil Mahdi Abdelhameed, Genetic variationswithin Leishmanaia donnvani parasites revealed by minisattelite DNA markers and RFLP analysis. (M.Sc) 2002.

• Tageldin A M Nour  Genetic characterization of Shhep Pox virus (M.Sc.)2002

• Rihab Bereir  Allel frequency and Genotype distribution in disease related genes among selected populations in the Sudan(M.Sc.)2002.

• Hiba salah, Genetic susceptibility to Kala-azar in Sudan (Ph.D) 2002.

• Safa Abdelfatah Fadl. 

• Nahla Osman Mohamed Ali (Ph.D.) Faculty of vetrinary sciences, University of Khartoum.

• Rania S Giha (M.Sc.), A possible role for Global Methylation in cancer pathogeneisis among sudanese breast cancer patients. (2004).

• Abdelbadeih A M Elhassan (M.Sc.), The genetic diversity of two ethnicaly different populations in eastern Sudan based on four SNPs in the 5q31-33 region. (2006).

• Sara M Ali (M.Sc.). Frequency of common fusion genes among sudanese ALL patients (2006).

• Nevein Saleh.(M.Sc). Frequency of hemoglobin S and C and their association with malaria episodes in two populations of different ethnic origin in eastern Sudan (2006).

GRANTS  AWARDED:

• Principal investigator for the following grants:

• The genetic diversity of Leishmania parasites from Sudan based on DNA and   protein polymorphism (TDR/ World Health Organization).1995-1997

• Wellcome Visiting Research Fellow, University of Cambridge, 1997-1998 Department of Pathology, studying the Genetics of the parasite Leishmania donovani

• Leishmanin skin testing serology and the polymerase chain reaction in the establishment of man as possible reservoir for Leishmania infection (World Health Organisation). 1997-1998

• Characterization of a possible signal transaction  pathway for the action of the anttileishmanial drug Pentostam (Third World Academy of Science).

• Genetic epidemiology in Sudan (International Centre for Genetic Engineering and Biotechnology).1997-2000

• Kala-zar in the Sudan, The role of Host and parasite genetics in in determining Disease outcome,  (The Wellcome trust Collaborative Research Grant (Principal applicant) 1999-2002 .

• Detection of drug resistant malaria and tuberculosis supported by IAEA (RAF/6/025) regional project

• The epidemiological components of cutaneous leishmanas outbreaks in Tuti island, a field and simulation approach  (World Health Organization EMRO).  2002-2003.

• Genetic diversity and susceptibility to malaria . 2004- Part of the BioMalPar consortium funded by the European Union.

LANGUAGES:

• Arabic Mother tongue

• English: fluent speaking reading and writing skills.

• Spanish: modest knowledge